Notoginseng Formula Special Gout Granule

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The Pharmacological Mechanism Of Wuwei Xiaodu Decoction In The Treatment Of Gout

Wuwei Xiaodu Decoction, composed of Flos Lonicerae, Flos Dendranthematis Indici, Herba Taraxaci Mongolici, Herba Violae Philippicae and Nudicaulous Grounsel Herb, is firstly recorded in Golden Mirror of the Medical Tradition. It is recorded that Flos Lonicerae, Flos Dendranthematis Indici and Nudicaulous Grounsel Herb have the function of anti-inflammation and immunomodulation . Some researchers find that Herba Taraxaci Mongolici has the function of anti-bacteria, anti-oxidation, anti-inflammation, diuresis, anti-allergy, promoting immunity, and is beneficial for the stomach . Because of its strong effect of anti-pathogenic microorganisms, Herba Violae Philippicae is often used in the treatment of ulcers and carbuncle with symptoms like swelling and pain . It is believed that Wuwei Xiaodu Decoction can enhance the immunity of diseased mice and reduce the IL-10 to the normal level . Besides, another report also illustrates that Wuwei Xiaodu Decoction could increase the phagocyte index and phagocyte rate of macrophages, adjust the balance of flora and thus enhance the immune function .

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Advances In Experimental And Clinical Research Of The Gouty Arthritis Treatment With Traditional Chinese Medicine

et al.Zhaojun Chen

1School of Graduates, Beijing University of Chinese Medicine, Beijing 100029, China

2Department of Hand and Foot Surgery, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China

Abstract

1. Introduction

Gout is a crystal-related disease aroused by the sedimentation of monosodium urate , directly related to hyperuricemia caused by decreased uric acid excretion or purine metabolic disorders . Gout incidence rate and prevalence have risen steadily over the past few decades due to lifestyle changes, westernized diets, and an aging population . Typical acute gouty arthritis is more common in middle-aged, older men, and obese postmenopausal women. It is usually manifested as redness, bright, and significant tenderness in the single affected joints, especially when the first metatarsophalangeal joint is involved . A considerable part of the global population experiences gout every year . According to World Health Organization estimates, 3.9% of the people in the world suffer from gout . Gout owns multiple risk factors such as obesity, coronary heart disease, hypertension, diabetes or glucose intolerance, and lipid metabolism disorders. Acute episodes of arthritis, chronic joint injury, and joint malformations can decrease the living quality and cause disablement in some severe cases .

2. History of TCM for GA Prevention and Treatment

3. Therapeutic Effect Stimulated the Development of TCM for GA in Ancient China

References

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The Pharmacological Mechanism Of Tongfengan Mixture In The Treatment Of Gout

Tongfengan Mixture, composed of Herba Lysimachiae, Semen Sinapis, Thallus Ulvae Fasciata, Spora Lygodii, Rhizoma Smilacis Glabrae, Flos Carthami, Radix Paeoniae Rubra, Pseudobullbus Cremastrae, Rhizoma Alismatis and Rhizoma Corydalis, has the function of softening hardness and dissipating mass. It is found that in the rat models, Tongfengan Mixture can relieve the swelling, reduce the level of MSU crystals in the ankle joints, and reduce the inflammatory reaction, which may be achieved by reducing the inflammatory reaction in the blood . Liu et al. suggested that Tongfeng Mixture could inhibit the secretion of inflammatory factors like IL-1, TNF- and NF-B in the synovial tissue of the ankle joint of rats by clearing away urate crystals, and reducing the inflammation.

Other Signaling Pathways And Related Drugs

Furthermore, Jiang et al assessed activity of Celastrol, a pentacyclic triterpene, on protection against brain injury after acute ischemic stroke and showed Celastrol to protect the brain injury and promote the IL-33/suppression of tumorigenicity 2 axis-mediated microglia/macrophage M2 polarization. Indeed, IL-10 has been reported to promote M2 macrophage polarization for example, Luteolin could activate IL-10-dependent macrophage polarization and Tanshinone IIA, the active component isolated from Salvia miltiorrhiza, also polarized microglia into the M2 phenotype by activation of the estrogen receptor /IL-10 signaling pathway. In addition, Tanshinone IIA with anti-inflammatory and cancer activities could activate the Kruppel-like factor 4 and enhance M2 macrophage polarization by downregulation of miR-375 in control of atherosclerosis. Astaxanthin is a red lutein carotenoid with antioxidant and anti-inflammatory activities in a variety of cell lines and could inhibit microglia M1 activation against LPS-triggered inflammatory injury by downregulation of miR-31-5p expression in vitro and in vivo. 1,25-dihydroxy vitamin D3, the most active form of vitamin D3, could convert M2 macrophages into M1 macrophages by downregulation of miR-125b expression and upregulation of T-cell Ig-mucin-3 expression, while Han et al showed that berberine might promote M2 macrophage polarization partially by downregulation of long non-coding RNA Gomafu expression.

YuZhen Li, XiuHua Liu, in, 2019

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How Many Capsules Should I Take

For daily use, we recommend taking 1 capsule so that the natural ingredients can provide the optimal environment for your body to heal your joints.

For situational use in response to particularly painful joints, we recommend taking 2 to 4 capsules as needed for maximum strength relief.

Proper dosage is an individual process that depends on what works best for you and your body. We do not recommend taking more than 6 capsules per day.

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notoginseng, CA Tinctorius tuniclike,psammosilene root, BS BOLUS, G Sarcandra Herb

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Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

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Notoginseng Formula Special Gout Granule

Tianqi, or Notoginseng, is a well-known herb in Traditional Chinese Medicine for its pain-relieving and blood regulating effects. In TCM theory, the herb is said to promote circulation which can relieve pain, but also helps generate blood and stop excessive bleeding. This makes it perfect for those with chronic pain to take regularly or to promote healing after surgery or childbirth. This specific formula couples Notoginseng with other herbs to direct its pain-relieving effects to ease and heal gout.

Is Redimove Bottled Safely

Yes, every bottle of RediMove has a tamper-proof seal on the outside and inside of the cap. In addition, RediMove is carefully formulated in a GMP-certified, FDA-inspected facility in New York. Please visit ourQuality Control page to find out more about the rigorous process that we follow to ensure that every bottle of RediMove is safe.

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Our Research Confirms A Natural Approach Is Best

Dr. Jamison reveals new clinical evidence supporting the use of natural remedies for joint pain.

Scott Jamison, MD, has been a physician for over 30 years and is a leader in integrative medicine currently practicing in St. Louis. He and his team of researchers have been investigating the most effective alternative remedies to limit production of pro-inflammatory cytokines naturally.

“After months of research and testing, we arrived at a formula of 5 natural ingredients that outperformed all others in terms of safety and effectiveness,” Dr. Jamison states. “Following the results of the placebo-controlled clinical study, we decided to release the formula to the public.”

Popular Trigger Foods For Gout

Health Check Certified By:

Gout is a painful condition that affects 1- to 2-percent of North Americans through their lives. While gout can eventually go away on its own, it may last for years. Gout attacks last for about a week in length, and the majority of sufferers experience multiple attacks per year.

Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It crystallizes in the joints, with the big toe being the location in half of the cases. This is called podagra.

The symptoms of a gout attack can be controlled through nonsteroidal anti-inflammatory drugs and other medication. The prevention of gout attacks lies in diet. There are a number of foods that can trigger a gout attack. Recent studies have found that many of the vegetables we believe cause gout attacks in fact can decrease the risk. These foods include beans, peas, and leafy greens.

Here are 10 common trigger foods for gout. Try and avoid these or have them in moderation to keep your gout at bay.

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Promotion Of Reverse Cholesterol Transport

Reverse cholesterol transport is a multiorgan pathway that facilitates the removal of excess cholesterol from the artery wall to the liver . The process of RCT includes the following: cholesterol efflux, where these lipoproteins remove excess cholesterol from cells lipoprotein remodeling, where HDL undergoes structural modifications with possible impact on their function hepatic lipid uptake, where HDL releases cholesterol to the liver, for final excretion into bile and feces . Recent in vivo studies have suggested that the promotion of this process might reduce atherosclerotic plaque burden and cardiovascular events .

4.1Cholesterol efflux

Cholesterol efflux, the first and rate-limiting step of RCT, refers to the removal of excess cholesterol from macrophages. Two most important transporters contributing to regulating cholesterol efflux from cells have been described: ATP-binding cassette transporter A1 , which is responsible for the efflux to lipid-free APOA-I and ATP-binding cassette transporter G1 , which regulates efflux to mature HDL . Promoting the cholesterol efflux can effectively control the formation of foam cells and subsequent atherosclerosis caused by dyslipidemia .

4.2Lipoprotein remodeling

4.3Hepatic lipid uptake

Table 3. Induction of reverse cholesterol transport.

Lu Wang, … Shuwen Yu, in, 2021

Do I Have To Sign Up For Auto

Absolutely not! Auto-Delivery is optional for all of our products.

If you order RediMove every month, we recommend that you customize your own Auto-Delivery plan for your own convenience. All Auto-Delivery shipments come with free shipping and a full 30 day money back guarantee, no matter how many bottles you order. However, it is not required.

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Notoginseng Helps Stop Bleeding

In TCM, the herb is widely used to treat traumatic injuries and various kinds of bleeding. At home, Notoginseng can be used to make a drink that promotes the healing of minor scrapes and cuts. To make the drink for adults, double-boil 2 qian of Notoginseng in fresh water. For children, use 11.5 qian . This drink should be consumed only during the period of recovery and should not be used over the long term.

The Clinical Application Of Tcm Formulas In The Treatment Of Gout During The Remission Stage

During the remission stage of gout, the disease mechanism of TCM usually involves spleen deficiency with dampness accumulation. From TCM perspective, the abnormal production and excretion of uric acid is related to the dysfunctional of spleen, and tends to result in the increased content of SUA . Qin et al. used Tongyang Mizhuo Decoction, composed of Lizhong Pills and Wuling Powder to treat gout during the remission stage and found that the total effective rate was 94.4% and the SUA level was significantly reduced after the treatment. Emerging evidences from clinical observations indicated that patients during the remission stage were characterized by spleen deficiency with dampness accumulation. Quzhuo Tongbi Decoction is often used to treat spleen deficiency with dampness accumulation pattern and therefore it is suitable to treat gout during remission stage .

According to the TCM theory of treating disease before its onset, Peiyuan Huazhuo Decoction, is mainly used to prevent renal damage in patients with gout. TCM doctors found that the symptoms and the renal damage were relieved after the combination therapy, suggesting that the application of Peiyuan Huazhuo Decoction had the function of strengthening healthy qi and inducing diuresis .

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Glucosamine Is Doing More Harm Than Good

A 6 month placebo-controlled trial was ended early since glucosamine resulted in worse joint pain.*

In a with 164 participants, subjects taking glucosamine and chondroitin reported significantly worse pain according to the WOMAC scale, which measures joint pain, stiffness, and physical function. This led the doctors to end the trial early in the interest of the subjects’ health.

But if glucosamine is so harmful, why do 20% of adults still take it?

The answer lies in the placebo effect. When people take action to address a problem, even simply swallowing a pill can convince your mind that your body feels better.

The Pharmacological Mechanism Of Peiyuan Huazhuo Decoction In The Treatment Of Gout

Peiyuan Huazhuo Decoction is composed of Rhizoma Polygonatum Sibirici, Semen Cuscutae, Radix Astragali, Rhizoma Smilacis Glabrae, Semen Coicis and Rhizoma Corydalis. Yang et al. found that Radix Astragali could increase the glomerular filtration rate. It was also found that Rhizoma Polygonatum Sibirici not only had a good effect of lowering SUA levels, but also reduced blood lipid and glucose . The herbs in this formula work together to treat lipid metabolism disorders, inhibit inflammatory reactions, prevent gout attack, and prevent renal damage in patients with gout.

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The Pharmacological Mechanism Of Tcm Formulas In The Treatment Of Gout

Emerging evidences have suggested that gout caused by monosodium urate deposition is related to disorders of purine metabolism and reduced uric acid excretion, so it is classified as a metabolic rheumatism. However, in recent studies it has been found that the pathogenesis is closely related to the mechanism of metabolism-inflammation-immunity . TCM treatment for gout, especially the formulas from Synopsis of Golden Chamber could interfere the mechanism of metabolism-inflammation-immunity .

Overview Of The Effects Of Cmm On Cardiomyocyte Apoptosis Under Various Stress Conditions

We employed PubMed to search the following terms: CMM and cardiomyocyte apoptosis or traditional Chinese medicine and cardiomyocyte apoptosis or herb and cardiomyocyte apoptosis or CMM/traditional Chinese medicine/herb and heart and apoptosis. According to the results of the PubMed research, it has been demonstrated that CMM effectively reduces cardiomyocyte apoptosis, including evidence for the effects of 43 active components , 18 compound CMM preparations, and 9 single herbs . These data suggest that CMM has beneficial effects on cardiomyocyte apoptosis. Based on the main indications in traditional Chinese medicine, we group the above CMM and summarize their effects on cardiomyocyte apoptosis.

Table 1. Inhibitory effects of active components of CMM on cardiomyocyte apoptosis and underlying mechanisms under various stresses.

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