Collagen And Gut Health
We know that collagen synthesis is a fundamental element to repairing a leaky gut. We also know that people with nutritional deficiencies are more susceptible to getting a leaky gut. But did you know that the two are actually related?
Believe it or not, leaky gut is actually a mild form of scurvy in the gastrointestinal tract.
Scurvy is a disease caused by chronically low levels of vitamin C and when left untreated, it can turn into a vitamin C deficiency.
Vitamin C is a cofactor to collagen productionmeaning its vital for collagen synthesis and formation of collagen throughout your body. Without it, your collagen production shuts down and your health can pay the price. This is why taking a collagen supplement is crucial for anyone with nutrient deficiencies, especially if they have a leaky gut.
Helps Repair The Intestinal And Stomach Lining
Want to know how you can heal the intestinal and stomach lining? Try supplementing with collagen peptides! Science has identified collagen synthesis as an important component in the process of repairing and healing the intestinal lining. When there is damage or inflammation to the intestinal lining, new smooth muscle cells are made to heal the stomach lining and the intestinal wall. Scientists have found that collagen production in the intestine is greatest when smooth muscle cells are being generated during healing. Thus, collagen is a key component to healing the intestinal wall. Supplementing with collagen may help to repair and heal the stomach lining. 3
Gout And Supplements: What You Need To Know Arthritis
All I found for gout was a 2005 study about the importance of the intestinal tract in the elimination of uric acid but it seems more research needs to be done in regards to gout and leaky gut. There is a new study though from the University of Otago that a gene called PDZK1 which controls the amount of uric acid gets excreted from the kidney. Is there anything you can eat to help reduce or prevent symptoms of gout? According to Versus Arthritis’ The State of Musculoskeletal Health 2019 report, around 1 in 40 people in the UK have gout. 1 That amounts to around 1.6 million individuals. Here we uncover more about gout and share seven diet tips that could help you with how to treat gout
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Joint And Bone Health
To date, there are more than 60 studies about HC efficacy in reducing collagen damage, osteoarthritis , and osteoporosis . These results, as well as a high level of tolerance and safety, can make taking HC appealing for long-term use in bone and joint degenerative diseases.
Recent findings include a study of 51 postmenopausal women with osteopenia that found that the addition of HCs to calcium and vitamin D supplements may enhance bone metabolism.
In another study of 250 subjects with osteoarthritis of the knee, participants were given 10 grams of HC daily for six months. At the completion of the study, there was a significant improvement in knee joint comfort, based on both visual analog and pain scale assessments. Subjects with the greatest joint deterioration benefited the most.
Benefits Of Hyaluronic Acid Supplements
Hyaluronic Acid is in all connective tissues, and it has the unique ability to help bind collagen with elastin. The absence of hyaluronic acid in the body will directly lead to less lubrication in the joints and less elasticity of the skin.
According to a study published in Current Rheumatology Reports,
HA , found in a number of body tissues, is altered in the presence of osteoarthritis with decreased molecular weight and concentration resulting in impaired viscoelasticity. Hyaluronan preparations have been shown to decrease pain and increase function in patients with osteoarthritis of the knee.
Low-levels of hyaluronic acid is also responsible for the increase in saggy or wrinkled skin that comes with age, as well as also cartilage destruction throughout the body. According to a study published in the International Journal of Dermatology,
We propose that the variations of the levels of hyaluronic acid in the dermis in aging could account for some of the most striking alterations of the aged skin, including decreased turgidity, less support for microvessles, wrinkling, and altered elasticity.
The amount of hyaluronic acid in your body reduces as you age and the only natural source of hyaluronic acid is the connective tissues of animals.
Additionally, similar to BioCell Collagen supplements and unlike many other supplements, there is legitimate scientific research backing the effectiveness of hyaluronic acid supplements.
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Who Can Get Leaky Gut
Anyone can have a leaky gut without even knowing it. But according to research conducted by the Department of Biomedical Sciences and Pathobiology at Virginia Tech, those with autoimmune diseases, like celiac disease, Crohns disease, and IBD, for example, are especially susceptible because they are more sensitive to changes in the digestive system.
Molecular Evidence For Possible Pathological Link Between Gout And Oa
Gout may promote cartilage degradation due to the direct effects of MSU crystals. MSU crystals have been shown to inhibit human chondrocyte viability and function in vitro, in a dose-dependent manner . Similar phenomena were observed in ex vivo cartilage explant cultured with MSU crystals, which led to a rapid increase in expression of the degradation enzymes aggrecanase , and reduction in formation of the matrix proteins aggrecan, versican, and collagen type 21 . From a study of 7855 cadaveric talar surfaces of ankles from 4,007 donors, deposits of MSU and calcium pyrophosphate dihydrate crystals were located in regions that were subjected to biomechanically stress or joint instability. Crystal deposits were strongly associated with cartilage degradation, and immunohistological changes of cartilage degradation and repair . However, a minority of talus with crystal deposits showed no evidence of cartilage degeneration and therefore, cartilage damage may not be a pre-requisite for crystal deposition.
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Bovine Collagen Can Be Your New And Natural Topical Treatment Too
Imagine that! Bovine collagen has been reported to help with a few common external issues, including itchy symptoms due to anal pruritus and hemorrhoids. It can also aid in improving acne, though this is a benefit whether you consume the collagen or directly apply it in cream form onto the problem spots.
Collagen Can Have Possible Implications In Gut Health
According to Meghan Lyle, MPH, Registered Dietitian, Nutritionist, and Arivale Coach, “Though collagen peptides are all the rage right now, the benefits of their use are still under study. In some clinical trials, there have also been some side effects reported.
In several studies, gastrointestinal side effects have been noted with the use of collagen supplements: some patients notice constipation when they begin to include collagen peptides as part of their supplement regime. Others notice, though more rarely, a reduction in appetite. Its always best to speak with your doctor when adding new supplements to your regimen, particularly in an effort to avoid medication interactions.”
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It May Cause Kidney Stones
One big collagen side effect on kidneys is the possibility of developing kidney stones.
According to Schoenfeld, “If a person has a history of calcium oxalate kidney stones, it is a good idea to take it slow when adding collagen to the diet, starting with no more than 5-6 grams per day .
One of the amino acids that collagen is rich in, hydroxyproline, can be converted into oxalate and excreted through the kidneys into the urine. Under the right circumstances, this could trigger a kidney stone to form. Always drink plenty of water when adding collagen to the diet.”
It may take a beating to your kidneys, but there is rarely any collagen side effects on livers. So, yay?
Interactions With Other Drugs
“Patients should consult with their doctor before taking collagen supplements to rule out any interactions with medications or supplements already in your daily regimen,” Dr. Chimento says. These interactions tend to be pretty specific. For instance, wound-repair gel containing collagen is known to interact poorly with certain topical anesthetics.
Chatting to your doctor is particularly important if you experience any digestive problems when it comes to collagen supplements. That might prevent the active ingredients in drugs from being fully absorbed in your stomach.
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Evidence Of Associations From Epidemiologic Studies
Subjects with OA in various sites had higher serum uric acid level compared to healthy controls. From a population-based cross-sectional study, independent associations between serum uric acid concentration with hand OA, and OA of other body sites were revealed . Several subsequent population-based cross-sectional studies and cohort studies have noted positive associations of uric acid concentration with OA, but these associations became insignificant when body mass index was controlled as confounder. On the other hand, uric acid levels at the highest tertile may be associated with OA. In a cross-sectional study, the highest serum uric acid tertile were associated with generalized OA in subjects who had undergone arthroplasty for hip OA, but not with those who had undergone arthroplasty for knee OA . Another cross-sectional study involving over 4,000 participants in China has shown that women with the highest tertile of uric acid showed the highest degree of radiographic features suggestive of knee OA after adjusted for various confounding risk factors including BMI . Recently, a study of knee OA subjects without gout showed that serum uric acid levels significantly distinguished non-progressors from progressors defined by joint space narrowing on radiography over 24 months . We summarized the evidence from epidemiologic studies in Table 1.
Table 1. Summary of epidemiologic evidence of hyperuricemia or gout with OA.
Collagen And Joint Health
Another relatively large body of research connected supplementing with hydrolyzed collagen to overall joint health in athletes.
One 24-week study looked at the effects of collagen supplementation in physically active athletes who suffer joint pain because of their sport. The researchers found athletes using hydrolyzed collagen had notably less pain than those taking a placebo.
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Foods To Avoid To Heal Leaky Gut
These are the foods to avoid to heal leaky gut:
- Wheat-based productsbread, pasta, cereals, wheat flour, couscous, etc.
- Grains that contain glutenbarley, rye, bulgur, seitan, triticale, and oats.
- Processed meatscold cuts, deli meats, bacon, hot dogs, etc.
- fast foods, potato chips, sugary cereals, candy bars, cakes, cookies, etc.
- Dairymilk, cheese, and ice cream.
- Refined oilscanola, sunflower, soybean, and safflower oils.
- Artificial sweetenersaspartame, sucralose, etc.
- Beveragesalcohol, carbonated beverages, sports drinks, and other sugary drinks.
What Is Bovine Collagen
Bovine collagen, or beef collagen, consists of Type I and Type III collagen. Judging from the name, you may have already guessed that bovine collagen comes from cows. This type of collagen can be made into in two different consumable forms: the gelatin form and the peptide, or hydrolyzed, form. Bovine collagen is now eaten widely around the world as both scientists validate and consumers experience the powerful health benefits it provides for our skin, gut, joints, and more.
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Collagen Is Vital To Our Entire Body
Collagen is found in our stomach lining, bones, joints, tendons, hair, and nails .
Regular proteins are used to build muscle tissue, make enzymes and other body chemicals, and serve as the building blocks of bones, skin, blood, and muscles. Collagen specializes in repairing parts of our body, including the largest organ: skin. Wear and tear is no joke, and collagen is the protein that knows this and tackles it head on, wherever it may be needed.
The issue with our bodys collagen? When we reach our twenties, our natural production of collagen starts slowing down and keeps dramatically decreasing as we age. In fact, collagen production decreases by 23% each subsequent year. So, while our bodies continue using and needing collagen, we arent replenishing it at the same rate as when we were younger. This can become quite a problem considering collagen is what keeps our teeth, hair, bones, eyelashes, skin, and joints young and at their optimum strength. One way you can regain collagen is through supplementing with bovine collagen.
Natural Gout Remedies And Treatment
Cut sugar and alcohol: Cutting sugar, especially by avoiding alcohol and excess fructose, is the most effective step you can take in reducing or preventing gout. Get rid of soda and any other processed foods or drinks that contain high-fructose corn syrup. Drink water instead of juice, and cut out high-sugar fruits, like bananas, grapes, watermelon, mangoes, and melons.
Drink water: Its also important to stay hydrated, to allow your body to excrete uric acid through your urine. .
Take vitamin C: To reduce uric acid levels, make sure your diet includes enough vitamin C, or try adding a supplement. Several studies show that a daily dose of 500mg vitamin C can significantly lower uric acid levels.Plus, vitamin C is a very safe supplement: because its water-soluble, your body can get rid of any extra in your urine.
Take potassium citrate: Potassium citrate is another supplement that can help lower uric acid levels. Commonly used to prevent kidney stones , potassium citrate acts by increasing the pH of your urine, making it more alkaline and preventing crystals from forming. In this episode of Bulletproof Radio, ketone expert Dr. Richard Veech recommends supplementing 50mg capsules to help your kidney excrete the uric acid.
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Replacing Lost Collagen Could Calm Joint Stiffness And Pain
Without the right amount of collagen, your cartilage can become compromised. And joint-centric conditions, like osteoarthritis, can become an increasing risk. In fact, research shows that the aging-related loss of collagen can lead to a higher risk for degenerative joint disorders.
But adding collagen back into your body, either through your diet or with the help of supplements, could counteract that risk. It might even help you soothe any joint pain youre already experiencing.
Research shows that increasing your collagen consumption can improve osteoarthritis symptoms, reducing overall joint pain. Multiple studies show that a significant reduction in joint pain is possible. In one study, athletes who took 10 grams of collagen per day for six months saw a significant decrease in joint pain both while walking and while at rest. Another research study found that adults who took just two grams per day for just over two months also saw a similarly significant improvement in their joint pain. They also found they were able to be more physically active than those who didnt give collagen a try.
Its thought that when you up your collagen intake, that extra protein accumulates in the cartilage between your joints. It may also stimulate your body to naturally create more collagen. As a result, theres less pain, less inflammation and better mobility.
What Supplement To Choose For Gout
At the end you need to take note of your dietary habits and see if you are avoiding any entire food groups. Take dairy for example, if you are not eating any dairy then its wise to supplement with a calcium and vitamin D for your shortfall on dairy. We gout sufferers need to supplement on fighting to get those uric acid levels healthy, so naturally a cherry supplement can help maintain healthy uric acid levels for many, some more than others, of course the severity of ones gout plays a big role as well.
Tart cherries contain powerful antioxidants called anthocyanins which is what gives cherries that distinct red color. In addition, tart cherries are one of the richest sources of anthocyanins 1 and 2, which help to block pro-inflammatory COX-1 and COX-2 enzymes. For more evidence and studies on gout and cherries make sure to read my post on the subject. Cherries have been shown in studies that they may lower levels of uric acid, as well they may reduce the number of gout attacks.There have also been other gout studies examining dietary supplements like vitamin C and skim milk powder that you can check out.
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Whats The Difference Between Collagen And Collagen Peptides
Collagen peptides are a special form of collagen in which the protein has already been hydrolyzed. Because peptides are in a fully broken down state, they are able to dissolve easily into most hot or cold liquids. Theyre also much easier to digest and absorb into the body, meaning peptides may be the best and fastest way to reap the gut benefits of collagen.
Pathogenesis Of Chronic Gout
Chronicity is a feature of gout. It results from chronic inflammation that follows recurrent attacks of gout. Chronic gout manifests by chronic synovitis, bony erosions, cartilage damage and tophi formation. This can be explained by different mechanisms. Presence of urate crystals in the synovium leads to stimulation of chondrocytes to produce inflammatory cytokines, nitric oxide and matrix metalloproteases resulting in cartilage damage , .
On the bone level, IL-1 and activation of receptor for nuclear factor B and RANK ligand pathway are key players in osteoclastogensis and the formation of bone erosions. Gouty erosions are characterized by having overhanging edges and partial preservation of joint space. Furthermore, osteoblasts release pro-inflammatory cytokines leading to erosions and bone destruction in addition to compromising their own bone formation function. In the intercritical phase, there is persistent low-grade inflammation in affected joints. The same cytokines responsible for the acute flare up can be found at lower concentrations inbetween attacks. Although chronicity may result even with the use of uric acid lowering drugs and appropriate management of acute flare ups, yet its incidence is lower compared to patients with recurrent inappropriately treated attacks. Chronicity can be decreased by long-term use of low dose anti-inflammatory agents such as colchicine and lowering SUA to safe levels , .
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