Pharmacist Tips For Naproxen
Nausea and stomach pain are common after taking naproxen . It’s best to take this medication with food or milk to help prevent these side effects.
If you are using the delayed-release or extended-release versions of naproxen , do not crush, chew, or break them. Swallow them whole.
If you’re using the liquid form of naproxen , shake the bottle well before each use. Be sure to use a medication dose cup, spoon, or syringe to measure out your dose. Using household teaspoons might cause you to take the wrong amount of naproxen .
Don’t use over-the-counter naproxen for more than 10 days for pain. If your symptoms don’t improve, stop taking this medication and talk to your provider.
If you normally take a daily aspirin, naproxen can stop it from working properly. There are other anti-inflammatory medications that don’t interact as much with aspirin. Discuss alternatives with your provider to make sure your aspirin keeps working.
Naproxen raises the risk of stomach bleeding, so tell your provider right away if you experience unexplained vomiting or stomach pain, dark-colored stools, or blood in your vomit or stool.
If you are allergic to aspirin, there is a chance you could be allergic to naproxen as well. Always discuss all allergies with your provider before starting any new medications.
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What Medications Are Similar
There are multiple types of NSAIDs, but their uses vary.
Other NSAIDs include, but are not limited to:
For example, aspirin can relieve aches and pains like the others, but it can also be used for heart problems. Toradol is usually administered as an injection in higher doses, and along with Voltaren, can help treat arthritis. In comparison, ibuprofen is mainly used to treat more mild aches and pains that can occur during menstruation, toothaches, and headaches.
Determining which NSAID is best for you depends on what you might need it for. For example, aspirin is very effective in reducing the risk of heart disease, whereas celecoxib is very effective when managing and treating gout while minimizing side effects.
NSAIDs can also vary in their severity of side effects. For example, celecoxib has been shown to have a greater risk of heart problems, while Naprosyn has been shown to have the lowest chance of heart problems.
Other Ways To Treat Gout
Medicine is considered the most effective treatment method for gout, but there are lifestyle changes you can make to manage your symptoms during a gout attack, or help prevent gout attacks from happening. Learn more about other ways to manage symptoms of gout during an attack here. Learn more about preventing future gout attacks here.
Educational content made possible by Horizon Therapeutics.
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How Can I Stay Healthy While Taking Naprosyn
Its important to take Naprosyn regularly and as directed to stay healthy and feel the full benefits of the medication. However, if directed by the prescriber, even prescription Naprosyn can be taken as needed and not always scheduled.
For regular use, try using daily pill boxes or inverting your medication bottle each time you take your dose so that you can track whether youve already taken it that day or not. Forgetting to take your medication on time can result in unnecessary pain.
In addition to taking your Naprosyn regularly, you should also exercise as much as you can tolerate and stick to a healthy diet.
What If I Forget To Take It
If you take allopurinol:
- once a day take the missed dose as soon as you remember. If you do not remember until the following day, skip the missed dose.
- twice or more a day – if you do not remember until your next dose is due, skip the missed dose and take the dose that is due.
Never take a double dose to make up for a missed dose.
If you often forget to take your medicines, it may help to set an alarm to remind you. You could also ask a pharmacist for advice on ways to help you remember to take your medicines.
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How To Take Naprosyn
This oral medication can be taken as an immediate or extended-release tablet, suspension form, or even topically. If you are taking the extended-release Naprosyn tablets, swallow them whole. Do not crush, split, chew, or try to dissolve them.
You can take Naprosyn with food, milk, or antacids to help decrease the chances of an upset stomach. If you are taking antacids, avoid taking any with ingredients such as magnesium oxide or aluminum hydroxide. If you are going to take an antacid, the recommendation is to take one containing aluminum and magnesium hydroxide. This is preferred over others.
If you are taking the EC tablets, make sure you take the antacid and your Naprosyn dose at least two hours apart from each other.
As a rule for all NSAIDs, Naprosyn treatment should begin with the lowest effective dose and be used for the shortest possible duration. If your pain is severe enough, your provider may prescribe opioid medications as well. Examples of opioids include hydrocodone, oxycodone, and codeine.
For less severe pain, you can take Naprosyn with other pain relievers like Tylenol. However, it should not be taken together with other NSAIDs such as ibuprofen, aspirin, and celecoxib.
How And When To Take It
The usual dose of allopurinol is 100mg to 300mg a day. Follow your doctor’s advice on how many tablets to take, and how many times a day.
You’ll have regular blood tests to monitor your uric acid levels. If your uric acid level does not come down far enough, your doctor may increase your dose .
If you have kidney or liver disease, your doctor may prescribe a lower dose and will monitor you more closely.
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Dosage For Gout Pain And Inflammation
Immediate-release oral tablet
- The initial dose is 750 mg, followed by 250 mg every 8 hours until the attack subsides.
Delayed-release oral tablet
- The initial dose is 1,000 to 1,500 mg once daily followed by 1,000 mg once daily until the attack subsides.
Immediate-release oral tablet
- The initial dose is 825 mg, followed by 275 mg every 8 hours until the attack subsides.
Dosage for people younger than 18 years hasnt been established.
Special dosage considerations
If youre older than 65 years, your body may process this drug more slowly. Your doctor may start you on a lowered dose so that too much of this drug doesnt build up in your body. Too much of the drug in your body can be dangerous.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.
Prevent The Next Gout Attack
Although the pain of a gout attack will eventually subside, its not an experience youre likely to forget. Fortunately, medication is available to help prevent gout flares.4 One example is Mitigare® 0.6 mg Capsules, which is FDA-approved to help prevent gout flares in adults.4 The safety and effectiveness of Mitigare® for acute treatment of gout flares during prophylaxis has not been studied, however.4 It is also important to keep in mind that Mitigare® is not an analgesic medication and should not be used to treat pain from other causes.4 To learn more about Mitigare and how it may be able to help you prevent gout flares4, talk with your doctor.
Important Safety Information
Colchicine 0.6 mg capsules are contraindicated in patients with renal or hepatic impairment who are currently prescribed drugs that inhibit both P-gp and CYP3A4. Combining these dual inhibitors with colchicine in patients with renal or hepatic impairment has resulted in life-threatening or fatal colchicine toxicity. Patients with both renal and hepatic impairment should not be given Mitigare®.
Fatal overdoses have been reported with colchicine in adults and children. Keep Mitigare® out of the reach of children.
Blood dyscrasias such as myelosuppression, leukopenia, granulocytopenia, thrombocytopenia, and aplastic anemia have been reported with colchicine used in therapeutic doses.
Monitor for toxicity and if present consider temporary interruption or discontinuation of colchicine.
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Be Mindful Of Stress Eating
Remember that diet changes alone are usually not enough to treat gout. Research shows that gout is much more likely due to genetics and kidney problems than from eating certain foods. That said, its a good idea try to follow guidance from the American College of Rheumatology to help reduce gout flares as part of your overall treatment plan:
- Avoid eating a lot of meat, shellfish, high-fructose corn syrup , and alcohol
- Limit high-purine foods
- Eat whole grains, fruits and vegetables, and lean protein sources
When youre at home, it may be harder to be careful about your diet, especially when there is increased stress as we are all seeing during the pandemic, says Dr. Fields. This is a good time for people with gout to try to be as careful as they can about their diet.
What To Know About Getting Infusions
Patients who take or are considering taking pegloticase , an infused medication that is used for chronic gout, may be concerned about continuing to receive these treatments, as they require going into a doctors office, outpatient clinic, or hospital. This medication is typically given every two weeks for six months until gout build-up is gone or your doctor decides you can stop treatment.
However, with this treatment, sticking to the recommended schedule can be critical. There is some evidence that if Krystexxa doses are spaced out longer than the usual two weeks, the likelihood of your body forming antibodies to Krystexxa® increases, says Dr. Fields. If that happens, Krystexxa may stop working for you.
You and your doctor need to strike the best balance for you in terms of continuing important therapy for your condition with avoiding coronavirus exposure, he adds.
If you have concerns, its a good idea to call your doctors office ahead of time to ask about what to expect in terms of new procedures. Examples of procedural changes for infusions include:
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What Can Increase Your Risk
A high level of uric acid in the blood is the main factor that increases your risk of developing gout. However, it’s still uncertain why some people with a high level of uric acid in the blood develop gout, while others with an equally high level don’t.
Other factors that may increase your risk of developing gout are outlined below.
Important Information About All Medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
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Study Summaries: Oral Steroids: A Safe And Effective Alternative
Janssens et al conducted a double-blind, randomized equivalence trial of 118 patients to compare the efficacy of prednisolone and naproxen for the treatment of monoarticular gout, confirmed by crystal analysis of synovial fluid. The study was conducted in the eastern Netherlands at a trial center patients were referred to by their family physicians. Those with major comorbidities, including a history of GI bleed or peptic ulcer, were excluded.
Participants were randomized to receive either prednisolone 35 mg* or naproxen 500 mg twice a day, with look-alike placebo tablets of the alternate drug, for 5 days. Pain, the primary outcome, was scored on a validated visual analog scale from 0 mm to 100 mm . The reduction in the pain score at 90 hours was similar in both groups. Only a few minor side effects were reported in both groups, and all completely resolved in 3 weeks.
Challenges To Implementation: No Significant Barriers
We found little to prevent physicians from adopting this practice changer. Oral steroids are readily available and inexpensive, and most primary care clinicians regularly prescribe them for other conditions. This practice change recommendation should be readily implemented.
The PURLs Surveillance System is supported in part by Grant Number UL1RR024999 from the National Center For Research Resources, a Clinical Translational Science Award to the University of Chicago. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center For Research Resources or the National Institutes of Health.
PURLs methodology This study was selected and evaluated using FPINs Priority Updates from the Research Literature Surveillance System methodology. The criteria and findings leading to the selection of this study as a PURL can be accessed at www.jfponline.com/purls.
* Prednisone is the precursor of prednisolone and is activated in the liver. The activity of both drugs is comparable, and prednisone and prednisolone can be converted milligram to milligram. However, prednisolone may be preferred for patients with severe liver disease.
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Who Can And Cannot Take Naproxen
Most adults can be prescribed naproxen.
It can also be prescribed to children to treat:
- muscle and bone disorders for babies from 1 month
- diseases of the joints for children from 2 years
- period pain for children under 15
Adults and teenagers aged 15 and over can buy it from a pharmacy for period pain.
Naproxen is not suitable for certain people. Tell your doctor or pharmacist if you:
- have had an allergic reaction to naproxen or any other medicines in the past
- have had an allergic reaction to aspirin or other non-steroidal anti-inflammatory medicines , such as ibuprofen
- have or have had stomach ulcers, bleeding in the stomach or intestines, or a hole in your stomach
- have a blood clotting disorder
- are pregnant, planning to become pregnant, or breastfeeding
If You Are Having Repeated Attacks See Your Doctor
Some patients can go a long time between attacks. In fact, for 62 percent of patients the next attack will be more than a year away, and some won’t have another attack in the next 10 years. However, if you begin to have more frequent attacks, talk to your doctor about escalating treatment. People think its normal to have flares every now and then, but its not. The gout can be doing damage to your joints. It means you still have too much uric acid, says Shakouri. In particular, ask about allpurinol. It wont help with an acute attack but will help prevent future attacks by reducing uric acid production.
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Taking Naproxen With Other Painkillers
Do not take naproxen with ibuprofen or other NSAIDs.
If you often need to take extra painkillers with naproxen or for more than a few days, you should talk to your doctor or pharmacist.
Sometimes taking different painkillers together is a good way to relieve pain, but there may be other treatments you can try.
It’s OK to take other painkillers with naproxen for longer if your doctor has given them to you on prescription and told you to take them together.
If you’re unsure, talk to your pharmacist or doctor.
Overdose: What Happens If I Take Too Much Naprosyn
Taking too much Naprosyn can cause some common and less severe symptoms, including:
- Difficulty breathing
If you overdose on naproxen and go to the hospital, there are various methods of treatment to remove naproxen from the body. You may need to vomit or take activated charcoal to prevent further drug absorption.
In some instances, you might undergo a procedure called osmotic catharsis. You would only need osmotic catharsis if substantial amounts of Naprosyn are taken or if you are taken to the hospital within four hours of the overdose.
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How To Cope With Side Effects Of Naproxen
What to do about:
- confusion if naproxen makes you feel confused, speak to your doctor.
- headache make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Headaches should usually go away after the first week of taking naproxen. Talk to your doctor if they last longer than a week or are severe.
- ringing in the ears if this lasts for more than 1 or 2 days, speak to your doctor as they may need to change your treatment.
- changes in vision do not drive until this side effect has worn off.
- feeling sleepy, tired or dizzy as your body gets used to naproxen, these side effects should wear off.
- dizziness if naproxen makes you feel dizzy, stop what you’re doing and sit or lie down until you feel better.
- rashes it may help to take an antihistamine, which you can buy from a pharmacy. Check with the pharmacist to see what type is suitable for you.
Mayo Clinic Q And A: Treating Gout Involves Combination Of Lifestyle Changes Medication
DEAR MAYO CLINIC: Years ago, I had gout in my toe, but I didn’t need medication other than ibuprofen. After it went away, I never had any other issues. But over the past few weeks, it has come back and is painful. Is there anything that I can do to reverse it at this point? What treatments are available?
ANSWER: Gout is a common form of inflammatory arthritis that can flare up quickly, causing intense pain. Successfully treating gout involves a combination of lifestyle changes and medication. Maintaining those changes over time can help keep gout at bay, and you may need to take medication long term, too.
Gout develops as aresult of urate crystals building up in a joint. Those needle-like crystalsform when you have high levels of uric acid in your blood. Your body producesuric acid as it breaks down purines substances found naturally in the body,as well as in certain foods and beverages. Normally, uric acid dissolves inyour blood and passes through your kidneys into the urine. But in some cases,your body makes too much uric acid, or your kidneys flush out too little uric acid,and it builds up to form urate crystals.
Although gout canaffect any joint, it most often occurs at the base of the big toe. Symptoms includesignificant joint pain, swelling, tenderness and redness. Gout symptoms usuallydevelop quickly, and they can linger from several days to several weeks.
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