Before Taking Indomethacin For Gout
At all times you should seek your physicians advice before taking any medication, and be guided by them. Your doctor will make a professional assessment of your suitability for Indomethacin before prescribing it for gout. However, before that, you should ensure that you tell your doctor if you:-
- are allergic to Indomethacin, aspirin, other NSAIDs
- have other allergies
How And When To Take It
The usual dose of allopurinol is 100mg to 300mg a day. Follow your doctor’s advice on how many tablets to take, and how many times a day.
You’ll have regular blood tests to monitor your uric acid levels. If your uric acid level does not come down far enough, your doctor may increase your dose .
If you have kidney or liver disease, your doctor may prescribe a lower dose and will monitor you more closely.
Side Effects And Warnings Regarding Indomethacin
Indomethacin is a non-selective NSAID, which results in more possible side effects than some other NSAIDs. Common clinical side effects include:
- Gastropathy .
- Nephropathy .
- Platelet dysfunction .
- Fluid overload in patients with congestive heart failure.
In addition, some people have experienced potentially fatal, allergic-type reactions to indomethacin.
The warning label for indomethacin instructs users not to drive a vehicle or operate heavy equipment a warning you should definitely heed.
As a medication for gout, indomethacin is one of the most powerful NSAIDs on the market today. For this reason, it is fairly effective at knocking out a gout attack, but dont be surprised if you end up with a stomach ulcer, dizziness, confusion, and/or bizarre nerve sensations.
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Dosage For Moderate To Severe Ankylosing Spondylitis
Adult dosage
- Immediate-release capsule: Indomethacin is usually dosed 2 to 3 times per day and starts at a dose of 25 mg. Your doctor may increase your dose by 25 mg or 50 mg per day. The maximum dose is 200 mg per day.
- Extended-release capsule: The dose is 75 mg once or twice per day. The maximum dose is 150 mg per day.
Child dosage
- Immediate-release capsule:
- Indomethacin dosing for children is based on weight. Your doctor will determine the right dose for your child.
- A starting dose may be 1 to 2 mg/kg per day divided into 2 to 4 doses.
- The maximum dose is 3 mg/kg per day or 200 mg per day, whichever is less.
Indomethacin 50 Mg Gout
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The Mechanism Of Action Of Indomethacin And Naproxen
Now lets delve deeper and analyze these two medications. How do they really work? What causes all of their side effects?
Different from the other medications out there, the side effects of the NSAIDs may be explained through thorough studying of their own mechanisms, not just by staring at the numbers of the patients that fell prey to their own side effects.
NSAIDs hinder the production of the cyclooxygenase enzymes, which are accountable for the conversion of the arachidonic acids into prostaglandins. Meanwhile, since the prostaglandins are the ones accountable for the pain and inflammation as their defense mechanisms, youll not experience any pain and swelling when it isnt produced. Unluckily, this may leave the body susceptible to attacks. For short, taking either of the two medications may cause the suppression of the immune system hence leaving you unprotected against bacteria, viruses and some other foreign entities. This is particularly true when it comes to indomethacin, because indomethacin mutilates the white blood cells so itll not respond to any foreign invasions and will consequently not cause any pain.
Finally, all the NSAIDS cause gastrointestinal bleeding and peptic ulcer because the prostaglandins are also accountable for the mucus lining maintenance of the stomach. If you are going to disable the production of the prostaglandins, you will be disabling the maintenance of the mucus lining finally leading to an ulcer or even in bleeding.
Dosage For Moderate To Severe Osteoarthritis
Adult dosage
- Immediate-release capsule: Indomethacin is usually dosed 2 to 3 times per day and starts at a dose of 25 mg. Your doctor may increase your dose by 25 mg or 50 mg per day. The maximum dose is 200 mg per day.
- Extended-release capsule: The dose is 75 mg once or twice per day. The maximum dose is 150 mg per day.
Child dosage
- Immediate-release capsule:
- Indomethacin dosing for children is based on weight. Your doctor will determine the right dose for your child.
- A starting dose may be 1 to 2 mg/kg per day divided into 2 to 4 doses.
- The maximum dose is 3 mg/kg per day or 200 mg per day, whichever is less.
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How It Works For Gout
It is probably the most commonly used drug-based medication to relieve gout symptoms. Brand names are Indocin and Indocin-SR. Indomethacin is available in capsule, slow-release capsule, oral suspension and suppository forms.
Indomethacin works by helping to block or inhibit the production of prostaglandin molecules that are naturally produced by our bodiescells when body tissue is damaged. This damage occurs in gout victims due to the presence of urate crystals in the joints and surrounding tissue.
White blood cells flood the damaged site in order to limit and help repair the damage. Prostaglandins are produced during this process resulting in pain, inflammation, swelling, stiffness, etc. This is the bodys natural inflammatory process. By inhibiting prostaglandins production, Indomethacin helps to reduce these symptoms.
How To Use Indomethacin Oral
Read the Medication Guide provided by your pharmacist before you start using indomethacin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually 2 to 3 times a day with a full glass of water . Do not lie down for at least 10 minutes after taking this drug. If stomach upset occurs while taking this medication, take it with food, milk, or an antacid.
The dosage is based on your medical condition and response to treatment. In children, the dosage is also based on weight. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose or use this drug more often or for longer than prescribed. For ongoing conditions such as arthritis, continue taking this medication as directed. Discuss the risks and benefits with your doctor or pharmacist.
In certain conditions , it may take up to 4 weeks when this drug is taken regularly before you notice the full benefits.
If you are taking this drug on an “as needed” basis , remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.
Tell your doctor if your condition worsens.
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Indomethacin May Interact With Other Medications
Indomethacin can interact with several other medications. Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.
Below is a list of medications that can interact with indomethacin. This list does not contain all drugs that may interact with indomethacin.
Before taking indomethacin, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Indometacin Capsules Bp 50mg
This information is intended for use by health professionals
INDOMETACIN CAPSULES BP 50mg
Each capsule contains 50mg Indometacin PhEur.
Indometacin has non-steroidal analgesic and anti-inflammatory properties.
It is indicated for the following conditions:
active stages of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, degenerative joint disease of the hip, acute musculoskeletal disorders, gout and lumbago.
inflammation, pain and oedema following orthopaedic procedures.
treatment of pain and associated symptoms of primary dysmenorrhoea.
Since indometacin is not a simple analgesic, its use should be limited to the above conditions.
Posology
The dosage should be carefully adjusted according to the needs of the individual patient, starting with a low dose.
To reduce the possibility of gastro-intestinal disturbances, indometacin capsules should always be taken with food, milk or immediately after meals, or with an antacid and in chronic conditions start the therapy with a low dosage, increasing as required.
Adults: The recommended oral dosage range is 50-200mg daily.
Acute rheumatoid arthritis: Initially 25mg two or three times a day.
Chronic rheumatic disorders: 25mg two or three times daily. .
Sudden flare up of chronic condition: Increase if necessary, by 25mg daily until a satisfactory response is obtained, or a dosage of 150-200mg daily is reached. .
Gout: Acute attack: 50mg three or four times daily until symptoms subside.
Method of Administration
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Most Common Side Effects
The most common side effects that occur with indomethacin include:
- nausea
The indomethacin dosage your doctor prescribes will depend on several factors, which include:
- the type and severity of the condition youre using indomethacin to treat
- your age
- the form of indomethacin you take
- other medical conditions you may have
Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage thats right for you. Theyll ultimately prescribe the smallest dosage that provides the desired effect.
The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.
Is It Safe To Drink Alcohol While Using Indomethacin
Guest over a year ago
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Guest over a year ago
over a year ago
Hello there,
I agree with the poster above me, you shouldnt be drinkingalcohol together with Indomethacin. Your friend has point when it comes to theantibiotics, because if you are drinking alcohol while you are using antibioticsit may result in unsuccessful therapy. And then you will have to do everythingall over again, and nobody wants to drink medications longer then it isnecessary.
And I am sure that you are not addicted to the alcohol andthat you can go without it during drinking Indomethacin. If you are going outcontrol yourself and explain to your friends that you cant drink with themthis time, but that you will some other. I hope you will manage to controlyourself.
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How Indocin And Ibuprofen Are Different
One of the primary differences is how widely available Indocin and ibuprofen are. While anyone can purchase and take ibuprofen, your practitioner will need to write you a prescription for Indocin. Your healthcare provider may also recommend a high dose of ibuprofenmore than 400 mgwhich is available by prescription only.
Another major difference is in how often the medications have to be taken. Indocin is a long-acting medication that only needs to be taken once or twice per day. Many people like the convenience of only needing to remember one pill.
Ibuprofen, on the other hand, has to be taken three to four times per day, and your dose might involve multiple pills. However, some people like using an OTC medication to manage occasional flare-ups, without committing to taking a prescription medication daily.
While both Indocin and ibuprofen are used to treat osteoarthritisthe most common type of arthritisIndocin can also be used to treat gout, a form of arthritis characterized by acute episodes of intense swelling and pain in one or a few joints.
What If I Forget To Take It
If you take allopurinol:
- once a day take the missed dose as soon as you remember. If you do not remember until the following day, skip the missed dose.
- twice or more a day – if you do not remember until your next dose is due, skip the missed dose and take the dose that is due.
Never take a double dose to make up for a missed dose.
If you often forget to take your medicines, it may help to set an alarm to remind you. You could also ask a pharmacist for advice on ways to help you remember to take your medicines.
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What Are The Possible Side Effects Of Indomethacin
Get emergency medical help if you have signs of an allergic reaction or a severe skin reaction .
Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath.
Stop using indomethacin and call your doctor at once if you have:
- a skin rash, no matter how mild
- changes in your vision
- heart problems–swelling, rapid weight gain, feeling short of breath
- signs of liver or pancreas problems—loss of appetite, upper stomach pain , nausea, vomiting, diarrhea, unusual tiredness, itching, flu-like symptoms, dark urine, jaundice
- signs of stomach bleeding–bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds
- kidney problems–little or no urination, swelling in your feet or ankles, feeling tired or short of breath or
- low red blood cells —pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.
Common side effects may include:
- headache or
- dizziness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What Other Drugs Could Interact With This Medication
There may be an interaction between indomethacin and any of the following:
- ASA
- alpha agonists
- aminoglycoside antibiotics
- angiotensin converting enzyme inhibitors
- angiotensin receptor blockers
- apixaban
- beta-adrenergic blockers
- bisphosphonates
- calcium channel blockers
- celecoxib
- corticosteroids
- cyclosporine
- diuretics
- drospirenone
- 5-ASA medications
- glucagon
- low molecular weight heparins
- metformin
- other non-steroidal anti-inflammatory medications
- obinutuzumab
- prostaglandin eye drops
- quinolone antibiotics
- rivaroxaban
- selective serotonin reuptake inhibitors
- serotonin/norepinephrine reuptake inhibitors
- sodium phosphates
- tricyclic antidepressants
- vancomycin
- Vitamin E
- warfarin
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.
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How Should Indocin Be Taken
Indocin is available in capsules in strengths of 25 and 50 mg, in suspension strength of 25 mg per 5 ml and as a suppository in strength of 50 mg per suppository. Initial doses usually start at 25 mg three times daily. Indocin IV for Injection Sterile Vial contains 1 mg Indocin and is used by specialists in infants to close a patent ductus arteriosus in the heart and is not commonly prescribed. Indocin ordinarily should not be prescribed for pediatric patients under 15 years old.
Medication Options For Uric Acid Lowering
It is important to note that whenever starting a uric acid lowering treatment, there is a risk of precipitating a gout flare. A plan should be in place for management if this occurs. This generally can be avoided with the co-administration of prophylactic medications along with the uric acid lowering therapy.
Probenecid
Probenecid may be given to patients with decreased clearance of uric acid by the kidney and normal renal function. In general its use should be limited to patients under the age of 60. Probenecid acts by inhibiting reabsorption of uric acid in the proximal tubules of the kidney. Starting dose is at 500 mg to 1000 mg daily and increased to 1500 mg to 2000 mg as needed. Occasionally higher doses are needed. Probenecid may precipitate renal stone formation and good oral hydration should be encouraged. Probenecid is contraindicated in patients with renal stones and in patients with urate nephropathy. Probenecid given inappropriately to patients with hyperuricemia due to overproduction of uric acid can cause renal stones and urate nephropathy.
- uricosuric
- useful in patients with decreased renal clearance of uric acid
- can only be used if creatinine clearance > 40 cc/min
- must have 24 hour urine for uric acid < 800 mg/dl
- can be used in renal failure
- increased risk of renal stones
Allopurinol
Pegloticase
- pegylated porcine uricase
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