Sunday, February 18, 2024

Can Gout Damage Be Reversed

When To Talk With Your Doctor

Allopurinol – How it works in treatment of GOUT

If youve been using a particular management strategy for your arthritis, but you feel like its not working as effectively as it once did, contact your doctor. Its possible that you will have more success with a different type of treatment.

If your symptoms are worsening or new symptoms develop, thats another opportunity to discuss other treatment options with your provider.

Target Sua In Chronic Gout

Since it is clear that gout is the consequence of the accumulation of uric acid in the body, the logical way to treat the condition is to lower the sUA level and deplete the body urate pool. The clinical manifestations of gout are due to deposition of MSU crystals and if the crystals are dissolved completely and no new crystals can form, then the condition is cured. To achieve this, the sUA must be reduced below the saturation point of MSU under physiological conditions.

This has been recognized in recent evidence-based recommendations from the European League against Rheumatism Task Force for Gout, which recommend that the sUA should be reduced to a target of 6 mg/dl . The authors of the recommendations point out that the target sUA level should be linked to the saturation level of MSU rather than to the normal laboratory range, which can vary between populations and with time. It is also acknowledged in the guidelines that the target sUA may vary depending on the characteristics of the patient and a lower target may be appropriate in patients with extensive crystal deposition. The British Society of Rheumatology has also published guidelines for the management of gout and these recommend a stricter sUA target of < 5 mg/dl .

How Does Alcohol Impact Recurrent Attacks Of Gout

Alcohol consumption has been shown to trigger attacks of gout. In a 2-year study conducted in the United Kingdom, 550 participants self-reported the triggers of their most recent gout attacks. The findings from the study showed that alcohol consumption was responsible for about 1 in 7 attacks of recurrent gout.9 This was significantly higher than other self-reported triggers of gout, such as dehydration and consumption of red-meat or sea-food .

In an even larger study conducted in New Zealand that involved over 2,000 men and women with gout, alcohol was the self-reported trigger of almost half of all gout attacks.10 A study conducted in an outpatient gout clinic in China reported similar findings, with over 60% of the patients that presented with attacks of gout reporting alcohol consumption prior to the attack.11

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Underlying Bone Damage From Gout Can Occur Even If Youre Not Currently In Pain

If you have gout, a type of inflammatory arthritis characterized by a buildup of uric acid in the joints , you know how much an attack hurts. What you might not know is that underlying damage may be occurring even when you arent in pain.

According to a new study, published in Arthritis Care & Research, as many as 44 percent of people with gout have bone erosions.

The researchers, from Shanghai, conducted ultrasounds on 980 gout patients. Study participants were most apt to have evidence of bone damage if they were older , had been living with the disease for longer , and had had more frequent attacks .

High blood pressure, high blood sugar, and kidney disease were also associated with an increased likelihood of having bone erosions among gout patients. People whose imaging tests showed visible evidence of tophi a deposit of uric acid crystals around a joint were much more apt to have bone deterioration, too.

According to the authors, this is the first study of its size to assess how common bone erosions are in gout patients. While pain from a gout attack usually abates within a few days, these findings suggest that more people may need to be on long-term medication to decrease levels of uric acid in order to decrease the number of future attacks as well as avoid or limit bone damage.

If you have gout, dont ignore it. Talk to your doctor and discuss gout treatment options, which include different types of medication as well as dietary and other lifestyle changes.

Does Alcohol Increase The Risk Of Gout

Powerful Home Remedy For Curing Gout In 7 Days

Alcohol is a major source of purines, the chemical compounds that are broken down by the body to produce uric acid. Different types of alcohol vary in the amount of purines they contain, with regular beer having the highest purine content and spirits the lowest.3 Research has shown that drinking alcohol leads to increased uric acid levels in the blood,4 and evidence from several studies have shown that alcohol consumption is a major risk factor for gout.5-6

If you or a loved one is struggling with an addiction to alcohol and are seeking treatment, call us today at You can also use our insurance verification form below.

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The Role Of Physical Activity In Prevention Of Gout

Along with diet, physical activity can help with weight loss, and gout has been associated with being overweight.7 in patients with well-established gout, especially if X-rays have demonstrated joint damage in the foot, a low-impact exercise program is reasonable. An exercise program combined with diet in gout can reduce risk for attacks.7 If an attack seems to be coming on in the lower extremity, patients are well-advised to try to get off their feet, since impact seems to worsen gout attacks. Clues to an attack of gout coming on include local swelling, heat, redness, and tenderness in a joint, especially in the foot, ankle, or knee. Some patients have fever and chills as the first warning that an attack of gout is coming on.

Can Gout Damage Reversed

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Other Risk Factors For Gout

As mentioned, eating a lot of foods high in purines and taking certain medications can cause gout. However, there are other risk factors that can increase your chances of developing gout. Here are some of them:

  • High blood pressure
  • Diabetes
  • Kidney disease

Gout tends to run in families. If you have a close relative with gout, youre more likely to develop it as well.

Management Of Patients With Comorbidities

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It is important to consider comorbidities in gout patients . Renal function impairment function should be assessed by estimating creatinine clearance rather than relying on the serum creatinine level. In patients with renal impairment, the dose of allopurinol must be adjusted according to renal function , and some uricosuric drugs may not be effectivesuch as probenecid and sulphinpyrazonein patients with moderate renal function impairment, although benzbromarone may still show efficacy, although only at higher doses, in patients with moderate renal function impairment . Severe allopurinol toxicity has been associated with renal function impairment due to the accumulation of oxypurinol, its active metabolite, which is renally excreted , and not to a direct toxic effect on the kidneys. Although genetic predisposition has been recently reported in 100% of the Han Chinese showing Severe Cutaneous Adverse Reactions to allopurinol and in 55% of the patients of European ancestry , renal function impairment was the other, highly statistically significant, factor associated with SCAR in patients on allopurinol . In addition, the side effects of colchicine and NSAIDs may be more frequent in patients with renal dysfunction and prescription use should be restricted in renally impaired persons to treat acute flares and for long-term prophylaxis .

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What Happens At Your Appointment

The GP may ask about your diet and if you drink alcohol.

They may refer you to see a specialist and arrange a blood test and scan. Sometimes a thin needle is used to take a sample of fluid from inside the affected joint, to test it.

The blood test will find out how much of a chemical called uric acid there is in your blood.

Having too much uric acid in your blood can lead to crystals forming around your joints, which causes pain.

Who Is Affected By Gout

Gout can affect anyone. It usually occurs earlier in men than women. It generally occurs after menopause in women. Men can be three times more likely than women to get it because they have higher levels of uric acid most of their lives. Women reach these uric acid levels after menopause.

People are more likely to get gout if they have:

  • Obesity, or a lot of extra weight.

You are also more likely to develop gout if you:

  • Consume a diet high in animal proteins
  • Consume a significant amount of alcohol
  • Are on water pills .

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How Can An Attack Of Gout Be Treated

The management of an acute attack of gout is very different from the prevention of subsequent attacks.

Treatments used for prevention, such as allopurinol can actually make things worse if given during an attack, and so need to be held back until the attack has resolved for several weeks.

There are a number of measures that can help resolve an attack of gout. See Table 2 for summary of treatment strategies for acute gout. One principle is that treatment for an attack of gout should be instituted quickly, since quick treatment can often be rewarded with a quick improvement.

If an attack of gout is allowed to last more than a day or so before treatment is started, the response to treatment may be much slower.

Table 2: Medications to treat acute attacks of gout

  • Nonsteroidal anti-inflammatory drugs or COX-2 inhibitorsExamples of : Naproxen 500mg twice daily, indomethacin 25mg three times daily. Example of COX-2 inhibitor: celecoxib 200mg twice a day. Possible side-effects: Elevation of blood pressure, ankle swelling, upset stomach, ulcer . Use with caution if kidney or liver problems.
  • Anti-Inflammatory corticosteroidsExamples of : Prednisone 40mg first day, 30mg 2nd day, 20mg third day, 10mg fourth day. Possible side-effects: Elevation of blood pressure, elevation of blood sugar, mood changes. Short-term use, as in gout, generally much better tolerated than long-term use. Use with caution if diabetic.
  • Kidney Failure From Severe Dehydration

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    Severe dehydration is one of the most common causes of reversible kidney failure. Dehydration can be a serious life-threatening disorder. Read Hospitalized for Dehydration if you would like to understand what to expect when hospitalized for dehydration. Kidney failure is one of the most common complications of dehydration.

    During the early stages of every dehydration, your kidneys essentially shut themselves down to preserve water. Once the dehydration is corrected, the kidneys start to open up and quickly get your urine production back to normal. The blood tests I mentioned earlier help decide whether the kidney failure is still in the early rapidly reversible state. If the ratio of BUN to Cr is equal to or more than 20, your kidney failure from dehydration is likely in the early rapidly reversible stage.

    When the treatment of dehydration is delayed for several days, your kidneys go into the second stage of kidney failure. Small tubes inside the kidneys start to die off and you have structural damage inside the kidneys. This type of kidney failure is medically called Acute Tubular Necrosis or ATN. Necrosis simply means dying off. ATN is still reversible in most cases, but it takes longer to recover from. The tubes that die off will have to regenerate so that the kidney failure can ultimately be reversed. It may take a few weeks to reverse the kidney failure when ATN is present.

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    Treatment Of Acute Inflammation

    Gouty attacks probably result from a disturbance of the equilibrium attained between cells and crystals in the joint cavity during intercritical periods. The flares have been traditionally treated with NSAIDs, corticosteroids or colchicine, with generally good results in the majority of patients however, patients with gouty attacks often have multiple comorbidities that often limit the use of these therapies. A relatively recent systematic review suggests that NSAIDs , corticosteroids , adrenocorticotropic hormone , colchicine and canakinumab are all effective therapies for acute attacks . It is advisable to educate patients about treatment of acute attacks if they occur.

    What Can I Do To Strengthen My Bones

    The goal of treating osteoporosis is to slow bone loss and rebuild bones to help prevent breaks. A combination of diet, exercise, and medication when appropriate, can help strengthen your bones.

    Your provider will create an individualized treatment plan to protect your bones. Some of the diet and lifestyle strategies may include the following:

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    Medications For Acute Gout

  • Non-steroidal anti-inflammatory agents and COX-2 inhibitors are the mainstay of therapy of acute attacks of gout in patients who have no contra-indication to them. These medications include such agents as naproxen , ibuprofen , celecoxib , indomethacin and many others. These agents reliably decrease the inflammation and pain of gout. However, patients with ulcers, hypertension, coronary disease, and fluid retention must be careful with these agents, even for the short courses needed to resolve a gout attack. The doses of non-steroidal anti-inflammatory agents needed to resolve a gout attack are on the higher side, since full anti-inflammatory effect is needed. See examples of dosage in Table 2. Over-the-counter dosage levels, for example, ibuprofen at 200mg, two tabs three times a day, are often insufficient.
  • Corticosteroids, such as prednisone and methylprednisolone , are anti-inflammatory agents that are quite effective against gout attacks. Anti-inflammatory steroids are very different in action and side-effects as compared to male hormone steroids. Anti-inflammatory steroids have long-term risks, such as bone thinning and infection, but their risk for short-term therapy is relatively low. These agents can raise blood pressure and blood sugar, so can be a problem for those with uncontrolled hypertension or uncontrolled diabetes mellitus.
  • Can Kidney Failure Be Reversed

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    Certain types of kidney failure can be reversed. The treatment of reversible kidney failure usually needs hospitalization. Not all kidney failures are reversible, but reversible kidney failure is more common than you think. I have personally treated and reversed kidney failure many times in the last 15 years. Most patients I treated that were hospitalized for kidney failure didnt know their kidney failures could be reversed. I am writing this article to help other patients and families that are going through a similar situation understand reversible kidney failure.

    In this article, I will review different types of reversible kidney failures based on my personal experience as well as a review of relevant research articles.

    Here are 8 different types of kidney failures that can be reversed:

  • Kidney failure from bleeding
  • Kidney failure from severe dehydration
  • Kidney failure from heat exhaustion
  • Kidney failure caused by certain medications
  • Kidney failure from sepsis
  • Kidney failure due to an enlarged prostate
  • Kidney failure due to kidney stones blocking both kidneys
  • Kidney failure due to a bladder tumor
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    Can Gout Be Cured

    Cure is a very strong word, but we can certainly treat the gout and put it in remission by giving the treatment as mentioned, Dr. Meysami says.

    Whether to use the word cure may be a matter of semantics: A patients gout tendency may never go away but can be well-controlled. Treatments for gout are extremely good, and the vast majority of gout patients can expect to be cured, Dr. Fields says. Cured is in quotes since it means that gout flares can completely disappear, but the person would need to stay on their medicine.

    Gout progression, though, certainly isnt inevitable, which is close to the best news any gout patient can hear.

    Avoid Alcohol And Sugary Drinks

    The heavy consumption both of alcohol and of sugary drinks â such as sodas and sweetened juices â correlates with an increased risk of developing gout.

    Alcohol and sweetened drinks also add unnecessary calories to the diet, potentially causing weight gain and metabolic issues.

    2010 analysis of data from female participants in the Nursesâ Health Study found that gout risk decreased as coffee consumption increased.

    Women who consumed 1 to 3 cups of coffee per day had a 22% reduction in their risk of gout compared with those who drank no coffee. Women who consumed more than 4 cups of coffee per day had a 57% decrease in their risk of getting this condition.

    A handful of studies have also linked coffee consumption to a lower risk of cardiovascular disease. A 2014 systematic review and meta-analysis of long-term coffee consumption found that people who consumed 3â5 cups of coffee per day had the lowest risk of cardiovascular disease.

    As people with gout have a higher risk of cardiovascular disease, drinking coffee may help improve their overall health.

    2011 meta-analysis of 13 randomized controlled trials found that vitamin C significantly reduced levels of uric acid in the blood.

    Reduced uric acid levels could lower the risk of gout attacks. Research has not conclusively proven that vitamin C treats or prevents gout, however â only that it lowers uric acid levels.

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    Is Gout Permanent Or Can It Be Reversed

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